Lupus & antiphospholipid syndrome
Urinary acetylated protein as a biomarker of lupus nephritis: a prospective cohort study
Authors' conclusion
Urinary lysine-acetylated peptides are promising novel biomarkers for LN diagnosis and histologic assessment, complementing traditional markers, such as UPCR, and highlighting their clinical potential
Study context
- Population
- Patients with lupus nephritis (LN), systemic lupus erythematosus (SLE) without nephritis, AAV-GN, and healthy controls
- Participants
- 30 / 30 / 11 / 25
- Exposure
- Urinary lysine-acetylated peptides in LN vs SLE without nephritis, AAV-GN and healthy controls
- LNn = 30
- SLEn = 30
- AAV-GNn = 11
- Healthy controlsn = 25reference
- Outcome
- Diagnostic ability of urinary lysine-acetylated peptides to differentiate LN from other conditions (ROC analysis)
Methodological detailsLC-MS screening, multiple reaction monitoring quantification, ROC analysis
- LC-MS screening
- Multiple reaction monitoring quantification
- ROC analysis
Main finding
As reported in the abstract
Urinary lysine-acetylated peptides for LN diagnosis
| Group | AUC, urinary ALB-K36, LN vs AAV-GN |
|---|---|
| LN | 0.947 |
LN
AUC, urinary ALB-K36, LN vs AAV-GN0.947
- ALB-K36 had the highest diagnostic accuracy for LN vs AAV-GN
- AUC = 0.947
Observational data: associations, not effects.
Further findings
Peptides in LN with low proteinuria (UPCR < 500 mg/g)
- Peptides remained elevated in LN with low proteinuria
Histological activity index > 2: ALB-K36 combined with UPCR
- Combining ALB-K36 with UPCR improved diagnostic performance
- AUC = 0.706
Original publication
Urinary acetylated protein as a biomarker of lupus nephritis: a prospective cohort study. Arthritis Res Ther. Published 25 November 2025. doi:10.
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