Lupus & antiphospholipid syndrome
Dietary Intervention for Systemic Lupus Erythematosus patients based on HLA-DQ2 and DQ8 genotyping (DISH): a protocol for a randomised controlled study
Study context
- Population
- Patients with SLE with positive HLA-DQ2 or DQ8 genotypingplanned
- Participants
- 90 patients
- Planned comparison
- Low-gluten dietary modification for 12 weeks vs control, both continuing usual SLE medications
- Primary endpoint
- Disease activity (Mexican SLEDAI score) and quality of life (Lupus Quality of Life questionnaire)
Methodological details1:1 randomisation, Research visits at weeks 0, 4 and 12: clinical interview, blood sampling, dietary assessment and questionnaire, Other secondary outcomes: fatigue score, sleep quality, anxiety and depression, physical activity
- 1:1 randomisation
- Research visits at weeks 0, 4 and 12: clinical interview, blood sampling, dietary assessment and questionnaire
- Other secondary outcomes: fatigue score, sleep quality, anxiety and depression, physical activity
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Dietary Intervention for Systemic Lupus Erythematosus patients based on HLA-DQ2 and DQ8 genotyping (DISH): a protocol for a randomised controlled study. Lupus Sci Med. Published 24 November 2025. doi:10.
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