Autoinflammatory & rare systemic diseases
Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation
Authors' conclusion
Patients with recurrent fevers without molecular diagnoses represent a clinically heterogeneous group.
Study context
- Population
- Patients with recurrent fevers without molecular diagnosis (PFAPA, syndrome of undifferentiated recurrent fever (SURF) and uSAID) in European AID registries3 registries
- Exposure
- PFAPA vs SURF vs uSAID
- Outcome
- Evolution of symptoms in recurrent fevers without molecular diagnosis
Methodological detailsmultiregistry (3 European AID registries), retrospective application of classification criteria
- Multiregistry (3 European AID registries)
- Retrospective application of classification criteria
Main finding
As reported in the abstract
- Clinical presentation of PFAPA is variable; some patients did not fit conventional PFAPA criteria
- Some patients met criteria for neither PFAPA nor SURF
- Some patients exhibited symptoms characteristic of both PFAPA and SURF/undefined autoinflammatory diseases (uAID)
Observational data: associations, not effects.
Original publication
Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation. Pediatr Rheumatol Online J. Published 17 May 2024. doi:10.
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