Unique characteristics of anti-MDA-5 associated dermatomyositis in Southern California with a large Hispanic population
Authors' conclusion
ILD was the most common presentation of anti-MDA-5 dermatomyositis in our cohort and was associated with higher ferritin levels. Hispanic patients had a younger age of diagnosis than non-Hispanic patients. Necrotic skin lesions and inflammatory arthritis were frequently seen.
Study context
- Population
- Patients diagnosed with anti-MDA-5 DM, June 2015 to March 2023, four medical centres in Los Angeles, California; majority Hispanic population21 female (70 %)
- Participants
- 30 patients
- Exposure
- Hispanic vs Non-Hispanic
- Hispanicn = 22
- Outcome
- Clinical characteristics of anti-MDA-5 DM
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Hispanic
- 22 (73 %)
- Median age
- 40.5 years
- Hispanic patients diagnosed at younger age than non-Hispanic
- p = 0.025
- Inflammatory arthritis prominent; more males than females affected
- p = 0.027
- Amyopathic
- 13 (43 %)
- Interstitial lung disease (ILD)
- 25 (83.3 %)
- Higher ferritin level associated with ILD
- p = 0.049
- Deaths
- 6 (20 %)
- Deaths ascribed to rapidly progressive ILD
- 5 (17 %)
Observational data: associations, not effects.
Original publication
Unique characteristics of anti-MDA-5 associated dermatomyositis in Southern California with a large Hispanic population. Semin Arthritis Rheum. Published 15 March 2024. doi:10.
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