Uncovering the “riddle of femininity” in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment
Authors' conclusion
Timing of initiation and dosage may be important factors modulating therapeutic effects of estrogen on cartilage.
Study context
- Population
- Preclinical animal models studying menopausal effects on cartilage38 manuscripts
- Comparison
- Post-menopausal vs age-matched non-menopausal animals
- Outcome
- Cartilage outcomes, post-menopausal vs non-menopausal animals (effect size; + greater in menopause, − greater in non-menopause)
Methodological detailsrigor and reproducibility analysis, ordinary differential equation models
- Rigor and reproducibility analysis
- Ordinary differential equation models
Pooled result
As reported in the abstract
- Cartilage outcomes worse in post-menopausal animals
- Post-menopausal vs Non-menopausal: 95% CI 0.75–1.72
- Post-menopausal vs Non-menopausal: 95% CI −4.96 to −0.96
- Post-menopausal vs Non-menopausal: 95% CI −4.87 to −0.56
- Post-menopausal vs Non-menopausal: 95% CI 2.43–5.79
Further pooled results
Menopause models and study conduct
- Ovariectomy as menopause model
- 92%
- Animals young at menopause induction
- 86%
- Most studies did not report inclusion criteria, animal monitoring, protocol registration, or data accessibility
Mathematical modelling of estrogen treatment
- Cartilage health may be improved with early initiation and higher doses of estrogen treatment
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Uncovering the “riddle of femininity” in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment. Osteoarthritis Cartilage. Published 6 January 2023. doi:10.
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