Ultrasound evaluation contrasts clinical disease activity evaluation in rheumatoid arthritis patients with concomitant anxiety or depression
Authors' conclusion
This study highlights the negative impact of anxiety and depression on RA patients in standard care, and underscores the challenges in disease activity assessment.
Study context
- Population
- Rheumatoid arthritis (RA) patients starting bDMARDs (82 % women, mean age 52 years, disease duration 10 years)
- Participants
- 201 patients
- Exposure
- RA patients with vs without anxiety or depression
- Anxious/depressedn = 109
- Outcome
- Ultrasonography (US) disease activity: PD and grey scale (GS) sum scores (36 joints and 4 tendons; range 0-120)
Methodological detailsunadjusted analyses, adjusted logistic regression, sensitivity analyses
- Unadjusted analyses
- Adjusted logistic regression
- Sensitivity analyses
Main finding
As reported in the abstract
PD sum score
Anxious/depressed
13
median · IQR 4–21
Not anxious/depressed
10
median · IQR 3–20
P = 0.53
Observational data: associations, not effects.
Further findings
Median
| Outcome | Anxious/depressed | Not anxious/depressed | P value |
|---|---|---|---|
| GS sum scoreSimilar | 28 (IQR 18–42) | 25 (IQR 14–41) | P = 0.51 |
- Composite disease activity scores · significantly worse in anxious/depressed
- P < 0.001
- Patient-reported outcomes, ESR, CRP and plasma calprotectin · worse in anxious/depressed
- all p ≤ 0.02
- Self-reported economy, sleep difficulties and not working
- all p < 0.001
- Patient-reported outcomes, ESR, CRP and plasma calprotectin: Sensitivity analyses confirmed these findings, except for CRP
- Self-reported economy, sleep difficulties and not working: worse economy and sleep, higher proportion not working in anxious/depressed
Original publication
Ultrasound evaluation contrasts clinical disease activity evaluation in rheumatoid arthritis patients with concomitant anxiety or depression. Semin Arthritis Rheum. Published 28 June 2024. doi:10.
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