Systemic sclerosis & Raynaud's
Ultrasound Classification of Finger Pulp Blood Flow in Patients With Systemic Sclerosis: A Pilot Study
Authors' conclusion
PDUS allowed a semiquantitative evaluation of FBPF in SSc patients and controls.
Study context
- Population
- Healthy controls and systemic sclerosis (SSc) patients, consecutively included
- Participants
- 86 vs 30
- Comparison
- SSc patients vs healthy controls
- SScn = 86
- Controlsn = 30reference
- Outcome
- Semiquantitative power Doppler ultrasonography (PDUS) classification of finger pulp blood flow (grade 0 [no signal] to 4 [signal on entire finger pulp, incl. subepidermal vascular network])
Methodological detailsconsecutive inclusion, semiquantitative 5-grade classification
- Consecutive inclusion
- Semiquantitative 5-grade classification
Main finding
As reported in the abstract
FPBF grade 0
P < 0.05
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Pathologic threshold <2 (grade 0 or 1) and DUs in SScGrade <2vs Grade ≥2 | 6.67 (2.31–19.21) | P < 0.0001 | |
| 0.050.21520Odds ratio (log scale) |
Finger pulp blood flow (FPBF) in controls after hot and cold challenge
- FPBF improved after hot challenge
- P = 0.024
- Cold challenge decreased FPBF
- P = 0.001
- Controls
FPBF correlation with resistivity index of radial arteries
- Spearman's correlation coefficient
- −0.50
- P
- P = 0.0049
Grade 0 and digital vasculopathy severity markers in SSc
- Grade 0 associated with digital ulcers (DUs) (current or past)
- P < 0.05
- Grade 0 associated with ulnar artery occlusion
- P < 0.05
- DUs less frequent with grade 4
- P < 0.05
- SSc patients
Original publication
Ultrasound Classification of Finger Pulp Blood Flow in Patients With Systemic Sclerosis: A Pilot Study. Arthritis Care Res (Hoboken). Published 22 September 2022. doi:10.
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