Type I interferon signature as a possible new marker for stratification of patients with juvenile idiopathic arthritis
Authors' conclusion
Although based on a small case series, our results may support the role of IS in better defining a subgroup of JIA subjects with stronger autoimmune features.
Study context
- Population
- Patients with juvenile idiopathic arthritis (JIA) (2001 ILAR criteria), excluding systemic JIA, referred to the Rheumatology Service of IRCCS Burlo Garofolo, Trieste, Italy35 F, 9 M
- Participants
- 44 patients
- Exposure
- Positive interferon score (IS) vs negative IS in JIA
- Positive ISn = 16
- Outcome
- Clinical correlates of increased IS
Methodological detailssingle-centre, consecutive recruitment, principal component analysis
- Single-centre
- Consecutive recruitment
- Principal component analysis
Main finding
As reported in the abstract
- Positive IS (≥3)
- 16
- Increased IS correlated with ≥5 involved joints
- p=0.013
- Increased IS correlated with increased erythrocyte sedimentation rate (ESR)
- p=0.026
- Increased IS correlated with hypergammaglobulinaemia
- p=0.003
Observational data: associations, not effects.
Original publication
Type I interferon signature as a possible new marker for stratification of patients with juvenile idiopathic arthritis. Clin Exp Rheumatol. Published 1 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →