Two-decade trajectories of gout: a multicentre cohort study of 10 658 Chinese patients with gout
Authors' conclusion
Over the past two decades in mainland China, there has been a noticeable trend towards younger onset of gout, alongside an increase in disease severity and metabolic comorbidities.
Study context
- Population
- People with gout from two geographically separate centres in mainland China, 2003–2022
- Participants
- 10,658 people
- Exposure
- Gout onset in second decade vs first decade
- Outcome
- Changes of age of onset and disease characteristics of gout
Methodological detailsmulticentre, two geographically separate centres, electronic medical records review, age-, sex- and disease duration-matched comparison
- Multicentre
- Two geographically separate centres
- Electronic medical records review
- Age-, sex- and disease duration-matched comparison
Main finding
As reported in the abstract
Age of gout onset, trend · 2003–2022
- Age of gout onset declined over the two decades
- Ptrend < 0.001
- Average onset age in 2003 (years)
- 42.0
- Average onset age in 2022 (years)
- 38.9
- Annual increase in proportion with onset age ≤19 years
- 5.8%
- Annual increase in proportion with onset age 20-29 years
- 9.6%
- P for trend, onset age ≤19 and 20-29 years
- Ptrend < 0.05
Observational data: associations, not effects.
Further findings
Lifestyle, second vs first decade (matched)
- Second decade more likely to have a history of smoking and alcohol consumption, less likely to engage in regular exercise
- P < 0.001
- Age-, sex- and disease duration-matched
Disease characteristics and comorbidities, second vs first decade
- Second decade had higher rates of s.c. tophi, frequent gout flares, nephrolithiasis, hypertension and diabetes, lower rates of dyslipidaemia
- P < 0.05
Original publication
Two-decade trajectories of gout: a multicentre cohort study of 10 658 Chinese patients with gout. Rheumatology (Oxford). Published 25 October 2025. doi:10.
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