Trends in Incidence of Chronic Heart Failure in Patients With Rheumatoid Arthritis: A Population-Based Study Validating Different Heart Failure Definitions
Authors' conclusion
The incidence of HF in patients with incident RA in the 2000s vs the 1980s was not statistically significantly different. Physician diagnosis of HF and ICD-9/10 codes for HF performed well against the Framingham criteria.
Study context
- Population
- Olmsted County, Minnesota residents with incident rheumatoid arthritis (RA) (age ≥ 18 yrs, 1987 ACR criteria met in 1980–2009), without heart failure (HF) prior to RA incidence/index datemedian follow-up 13.4 years
- Participants
- 905 participants
- Exposure
- Incident RA by decade of RA incidence (1980s, 1990s, 2000s); HF definitions (physician diagnosis, ICD-9/10 codes) vs Framingham criteria
- Outcome
- Incident HF events (any chart-reviewed method), 10-year cumulative incidence
- Follow-up
- 10 years
Methodological detailsCox proportional hazards models adjusted for age, sex and cardiovascular risk factors, validation of HF definitions against Framingham criteria
- Cox proportional hazards models adjusted for age, sex and cardiovascular risk factors
- Validation of HF definitions against Framingham criteria
Main finding
As reported in the abstract
10-year cumulative incidence of HF events by any chart-reviewed method
Observational data: associations, not effects.
Further findings
Performance of HF definitions (physician diagnosis; ICD-9/10 codes) vs Framingham criteria
- Physician diagnosis of HF and ICD-9/10 code-based definitions performed well vs Framingham criteria, with moderate to high sensitivity and specificity
Original publication
Trends in Incidence of Chronic Heart Failure in Patients With Rheumatoid Arthritis: A Population-Based Study Validating Different Heart Failure Definitions. J Rheumatol. Published 15 March 2023. doi:10.
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