Trends in Dermatopolymyositis Mortality, 1999–2022: A Nationwide Population‐Based Study, United States
Authors' conclusion
DPM mortality decreased at a higher rate than all-cause mortality until the pandemic, when it proportionately increased for both DPM and all causes. Females, younger individuals, and individuals of Black, Hispanic, and non-Hispanic other race and ethnicity had higher DPM mortality relative to all-cause mortality.
Study context
- Population
- Deaths in the United States, 1999–2022, CDC databases (Multiple Causes of Death 1999–2020; Provisional Mortality Statistics 2021 and 2022)deaths, 1999–2022
- Participants
- 12,882 vs 63,549,485
- Exposure
- Dermatopolymyositis (DPM) mortality vs non-DPM mortality
- DPMn = 12,882
- Non-DPMn = 63,549,485reference
- Outcome
- APC in age-standardized mortality rates (ASMRs) and in the DPM-ASMR to non-DPM-ASMR ratio
- Follow-up
- 1999–2022
Methodological detailsnationwide, joinpoint regression analysis, age-standardized mortality rates
- Nationwide
- Joinpoint regression analysis
- Age-standardized mortality rates
Main finding
As reported in the abstract
APC in ASMR until the start of the COVID-19 pandemic
DPM
−3.8%
Annual percent change (APC) · 95% CI −4.3%–-3.4%
Non-DPM
−1.2%
APC · 95% CI −1.5%–-0.9%
Observational data: associations, not effects.
Further findings
DPM-ASMR to non-DPM-ASMR ratio by subgroup
- Higher in females than males
- Higher in younger individuals (≤64 years) than those aged ≥65 years
- Higher in non-Hispanic Black, Hispanic, and non-Hispanic other race and ethnicity than White individuals
Premature death
- Odds of premature death higher for DPM than for non-DPM
Original publication
Trends in Dermatopolymyositis Mortality, 1999–2022: A Nationwide Population‐Based Study, United States. Arthritis Care Res (Hoboken). Published 27 November 2025. doi:10.
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