Long-term secular trends in dermatomyositis and polymyositis mortality in the USA from 1981 to 2020 according to underlying and multiple cause of death mortality data
Authors' conclusion
We identified two times as many DM/PM deaths using the MCD as those identified using the UCD. Similar downward DM/PM mortality trends were noted according to UCD and MCD. However, the year of significant decline in PM mortality was about 10 years earlier according to MCD than those according to UCD.
Study context
- Population
- Deaths with dermatomyositis (DM) or polymyositis (PM) mentioned anywhere on the death certificate and as the underlying cause of death (UCD), USA, 1981–1982 to 2019–202012,249 deaths (UCD)
- Exposure
- DM/PM mortality trends according to UCD vs multiple causes of death (MCD) data
- Outcome
- DM/PM mortality trends: Age-adjusted mortality rates (AAMRs) and annual percentage changes (APCs) by UCD and MCD data
Methodological detailsdeath certificate data, joinpoint regression analysis, age-adjusted mortality rates, underlying and multiple cause of death data
- Death certificate data
- Joinpoint regression analysis
- Age-adjusted mortality rates
- Underlying and multiple cause of death data
Main finding
As reported in the abstract
APC of mortality, by joinpoint segment
- DM, UCD: APC 1981-1982 to 1985-1986
- - 6.7%
- DM, UCD: APC 1985-1986 to 2003-2004
- - 0.1%
- DM, UCD: APC 2003-2004 to 2019-2020
- - 1.9%
- DM, MCD: APC 1981-1982 to 2003-2004
- - 1.2%
- DM, MCD: APC 2003-2004 to 2015-2016
- - 2.5%
- DM, MCD: APC 2015-2016 to 2019-2020
- 2.8%
- PM, UCD: APC 1981-1982 to 1989-1990
- 1.9%
- PM, UCD: APC 1989-1990 to 2005-2006
- - 2.3%
- PM, UCD: APC 2005-2006 to 2019-2020
- - 5.2%
- PM, MCD: APC 1981-1982 to 1991-1992
- 1.3%
- PM, MCD: APC 1991-1992 to 2019-2020
- - 4.1%
Observational data: associations, not effects.
Further findings
Number of deaths identified, 1981-2020
- UCD: total (DM; PM)
- 12,249 (3985; 7097)
- MCD: total (DM; PM)
- 23,608 (8264; 15,344)
Original publication
Long-term secular trends in dermatomyositis and polymyositis mortality in the USA from 1981 to 2020 according to underlying and multiple cause of death mortality data. Arthritis Res Ther. Published 31 January 2023. doi:10.
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