Vasculitis & polymyalgia rheumatica
Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Multinational Retrospective Study
An erratum to this article was published (J Rheumatol, Aug 2023 ↗)
Authors' conclusion
We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs.
Study context
- Population
- Patients with a definite diagnosis of AAV followed for ≥ 3 months, tertiary vasculitis centres in the EU, China, Turkey, Russia, the UK and the USA
- Participants
- 2,286 patients
- Outcome
- Cardiovascular events:
- Myocardial infarction (MI)
- Stroke
Methodological detailsmultinational, tertiary vasculitis centres, multivariate Cox regression
- Multinational
- Tertiary vasculitis centres
- Multivariate Cox regression
Main finding
As reported in the abstract
Cardiovascular events (mostly MIs) · median follow-up 62.0 months (IQR 22.6-100.0)
AAV
10.7%
245 events
Observational data: associations, not effects.
Further findings
Independent factors associated with cardiovascular events (CVEs) (multivariate Cox regression)
- Older age (55-64.9 yrs), HR
- 2.93 (95% CI 1.99-4.31)
- Smoking, HR
- 1.98 (95% CI 1.48-2.64)
- Chinese origin, HR
- 4.24 (95% CI 3.07-5.85)
- Pulmonary involvement, HR
- 1.50 (95% CI 1.09-2.06)
- Kidney involvement, HR
- 3.02 (95% CI 2.08-4.37)
Original publication
Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Multinational Retrospective Study. J Rheumatol. Published 15 January 2023. doi:10.
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