The Type I Interferon Signature Reflects Multiple Phenotypic and Activity Measures in Dermatomyositis
Authors' conclusion
The type I IFN score is independently associated with skin and muscle disease activity as well as certain clinical and serologic features in DM.
Study context
- Population
- Adult well-phenotyped dermatomyositis (DM) patients followed up during clinical care355 whole blood samples
- Participants
- 202 patients
- Outcome
- Association of organ-specific disease activity, autoantibodies and other clinical factors with systemic type I IFN activity (13-gene type I IFN score)
Methodological detailsRNA sequencing of whole blood, 13-gene type I interferon (IFN) score
- RNA sequencing of whole blood
- 13-gene type I IFN score
Main finding
As reported in the abstract
Type I IFN score
Stratified analysis (organ involvement, antibody class): correlation between changes in type I IFN score and skin disease activity, Spearman's ρ
0.84-0.95
Observational data: associations, not effects.
Original publication
The Type I Interferon Signature Reflects Multiple Phenotypic and Activity Measures in Dermatomyositis. Arthritis Rheumatol. Published 25 July 2023. doi:10.
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