The Role of IgM Anti‐acetylated Protein Antibodies and B Cells in the Origin of Antimodified Protein Autoimmunity in Rheumatoid Arthritis
Authors' conclusion
AMPA responses in RA do not appear to arise solely from AAPA IgM, as suggested by the lack of association between predisease AMPA IgM positivity and later AMPA evolution.
Study context
- Population
- Cord blood and serum of children up to three years old; individuals before rheumatoid arthritis (RA) onset; patients with RA
- Outcome
- Whether AAPA IgM serves as a precursor for other AMPAs, marking the initial breach of tolerance in RA
Methodological detailslongitudinal pre-RA sampling, single-cell sorting and sequencing
- Longitudinal pre-RA sampling
- Single-cell sorting and sequencing
Main finding
As reported in the abstract
before RA onset
Anti-acetylated protein antibodies (AAPA) IgM positive before RA onset
27.3%
Anti-citrullinated protein antibodies (ACPA) IgM positive before RA onset (significantly fewer than AAPA IgM)
11.7%
ACPA IgM positivity toward disease onset increased to
51.2%
Original publication
The Role of IgM Anti‐acetylated Protein Antibodies and B Cells in the Origin of Antimodified Protein Autoimmunity in Rheumatoid Arthritis. Arthritis Rheumatol. Published 22 June 2026. doi:10.
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