Increased Plasma Microbial tDR ‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response
Main finding · Baseline plasma tDR-1 concentrationResult — go to the resultFold difference 5.4-foldAuthors' conclusion
Higher plasma tDR-1 concentrations were associated with nonconversion to clinical RA in CCP3+ ARI.
Study context
- Population
- Anti-CCP3-positive individuals at risk of rheumatoid arthritis (RA)
- Participants
- 60 individuals
- Comparison
- Baseline plasma tDR-1 in later converters vs nonconverters to clinical RA
- Convertersn = 25
- Nonconvertersn = 35reference
- Outcome
- Baseline plasma tDR-1 concentrations by later conversion to clinical RA
Methodological detailsprospective follow-up of at-risk individuals, logistic regression adjusted for shared epitope, smoking, RF
- Prospective follow-up of at-risk individuals
- Logistic regression adjusted for shared epitope, smoking, RF
Main finding
Baseline plasma tDR-1 concentration
Fold difference
5.4-fold
P = 5.1 × 10-4
As reported in the abstract
Observational data: associations, not effects.
Further findings
Discrimination of conversion (AUROC)
- AUROC, risk factors alone
- 0.722
- AUROC, risk factors plus tDR-1 (P = 0.003)
- 0.902
In vitro type 1 interferon (IFN) response genes in THP-1 macrophages (tDR-1 vs scramble control)
- tDR-1 significantly down-regulated many type 1 IFN response genes
Original publication
Increased Plasma Microbial tDR ‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response. Arthritis Rheumatol. Published 22 June 2026. doi:10.
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