The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: A Large Cross‐Sectional Study
Authors' conclusion
We observed that genetic predisposition increased across pre-RA participant groups. The RA PRS differed in early classified RA and inflammatory pre-disease stages, regardless of ACPA stratification. HLA-SE prevalence differed between arthritis patients, particularly ACPA+ patients, and healthy controls.
Study context
- Population
- Healthy controls, patients with clinically suspect arthralgia (CSA) and early classified rheumatoid arthritis (RA) patients from the same Dutch population3 data sets
- Participants
- 1,015 / 479 / 84 / 395 / 1,146
- Exposure
- Healthy controls vs CSA patients vs early RA patients
- Healthy controlsn = 1,015reference
- CSAn = 479
- CSA convertersn = 84
- CSA nonconvertersn = 395
- RAn = 1,146
- Outcome
- RA PRS and HLA-SE across participant groups, unstratified and stratified for ACPA status
Methodological details3 separate data sets from the same Dutch population, stratified for anti-citrullinated protein antibody (ACPA) status
- 3 separate data sets from the same Dutch population
- Stratified for ACPA status
Main finding
As reported in the abstract
RA PRS
RA
1.31
mean · SD 0.96
CSA
1.07
mean · SD 0.94
CSA converters
1.12
mean · SD 0.94
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| RA PRS, ACPA- strata | CSA mean 1.05 (SD 0.94) · CSA converters mean 0.97 (SD 0.87) · RA mean 1.20 (SD 0.94) |
| RA PRS, ACPA+ strata | CSA mean 1.25 (SD 0.99) · Healthy controls mean 1.05 (SD 0.94) · RA mean 1.41 (SD 0.96) |
| HLA-SE prevalence | RA prevalence 0.64 · CSA prevalence 0.45 · CSA converters prevalence 0.60 · CSA nonconverters prevalence 0.42 |
| HLA-SE prevalence, ACPA+ strata | Healthy controls prevalence 0.43 · CSA nonconverters prevalence 0.48 · CSA prevalence 0.59 · CSA converters prevalence 0.66 · RA prevalence 0.79 |
RA polygenic risk score (PRS), ACPA- strata
- PRS distributions differed strongly between CSA/CSA converters and RA
RA PRS, ACPA+ strata
- Complete CSA group differed clearly from healthy controls and RA
HLA shared epitope (HLA-SE) prevalence
- More prevalent in RA than complete CSA; small difference RA vs CSA converters; larger difference CSA converters vs nonconverters
Original publication
The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: A Large Cross‐Sectional Study. Arthritis Rheumatol. Published 13 December 2022. doi:10.
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