Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients With Rheumatoid Arthritis
Authors' conclusion
Elevated inflammation early in RA diagnosis was associated with HF; this association was driven by HFpEF and not HFrEF
Study context
- Population
- Patients with rheumatoid arthritis (RA) in an electronic health record (EHR)-based cohort with data pre- and post-RA incidence; follow-up from RA incidence date
- Participants
- 9,087 patients
- Exposure
- Elevated vs non-elevated baseline inflammation
- Outcome
- Incident HF and its subtypes (HFrEF, HFpEF)
- Follow-up
- 5 and 10 years
Methodological detailsEHR-based, Cox proportional hazards models
- EHR-based
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident HF, elevated inflammation
HR, heart failure (HF) at 5-year follow-up
1.66
95% CI 1.12–2.46
HR, HF at 10-year follow-up
1.46
95% CI 1.13–1.90
HR, HF with preserved ejection fraction (HFpEF) at 5 years
1.72
95% CI 1.09–2.70
HR, HFpEF at 10 years
1.45
95% CI 1.07–1.94
Observational data: associations, not effects.
Further findings
Incident HF during 10 years of follow-up
- Developed HF
- 8.2%
Original publication
Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 12 December 2022. doi:10.
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