Spondyloarthritis & psoriatic arthritis
The natural history of chronic widespread pain in patients with axial spondyloarthritis: a cohort study with clinical and self-tracking data
Authors' conclusion
The development of CWP is predicted by higher levels of disease activity and burden at baseline. It also impacts future disease activity and wellbeing.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA); mean clinical study duration 120 weeks (range 27–277 weeks)97 with sufficient self-tracking data
- Participants
- 136 patients
- Exposure
- Chronic widespread pain (CWP) vs non-CWP
- CWPn = 46
- Outcome
- CWP (MSP, ≥6 of 9 body regions on Margolis pain drawing, at more than one timepoint)
Methodological detailslongitudinal, clinical and self-tracking data, logistic regression
- Longitudinal
- Clinical and self-tracking data
- Logistic regression
Main finding
As reported in the abstract
- Multisite pain (MSP) during at least one clinical visit
- 68 (50%)
- Incident MSP
- 8 (6%)
- Persistent MSP
- 16 (12%)
- Intermittent MSP
- 44 (32%)
- CWP
- 46 (34%)
Observational data: associations, not effects.
Further findings
Baseline predictors of CWP
- All baseline measures of disease activity, function, quality of life, sleep disturbance, fatigue and overall activity impairment were significant predictors of CWP
BASDAI, BASFI and self-tracking measures
- BASDAI and BASFI significantly higher with CWP
- Self-tracking: significantly worse pain, fatigue, sleep quality and stress with CWP
Original publication
The natural history of chronic widespread pain in patients with axial spondyloarthritis: a cohort study with clinical and self-tracking data. Rheumatology (Oxford). Published 5 December 2022. doi:10.
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