The lipid paradox is also present in early axial spondyloarthritis: results from the Swedish part of the SPondyloArthritis Caught Early (SPACE) cohort
Authors' conclusion
Inverse associations between systemic inflammation and lipids, particularly TC and ApoB, are present in early axSpA, similar to those shown for other inflammatory joint diseases.
Study context
- Population
- Patients with early axial spondyloarthritis (axSpA) (chronic back pain ≥3 months, ≤2 years; age at onset <45 years), Swedish part of the SPACE cohort
- Participants
- 64 patients
- Outcome
- Associations between lipids/lipoproteins (TC, ApoA1, ApoB) and inflammation (CRP, BASDAI, MRI sacroiliitis)
- Follow-up
- At inclusion
Methodological detailscohort-based (Swedish part of SPACE cohort), multivariable linear regression
- Cohort-based (Swedish part of SPACE cohort)
- Multivariable linear regression
Main finding
As reported in the abstract
Associations of lipids with CRP
- Negative associations with C-reactive protein (CRP) remained significant for total cholesterol (TC) and ApoB in multivariable models adjusted for age, sex, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and current smoking
- p = 0.048
Observational data: associations, not effects.
Further findings
- No significant associations for lipid parameters with BASDAI or inflammation on magnetic resonance imaging (MRI) of the sacroiliac joints
Original publication
The lipid paradox is also present in early axial spondyloarthritis: results from the Swedish part of the SPondyloArthritis Caught Early (SPACE) cohort. Scand J Rheumatol. Published 11 October 2024. doi:10.
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