Lupus & antiphospholipid syndrome
Macrophage colony-stimulating factor receptor/CD115 + non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis
Authors' conclusion
The non-classical monocyte subset in SLE is characterized by an expansion of M-CSF receptor/CD115+ cells that are associated with lupus nephritis and coexpress slan.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), healthy age-matched controls and patients with autoimmune connective tissue disease other than SLE
- Participants
- 39 / 32 / 16
- Exposure
- SLE vs healthy age-matched controls vs disease controls
- SLEn = 39
- Healthy controlsn = 32reference
- Disease controln = 16
- Outcome
- Phenotype of non-classical monocytes (CD115, CD116, slan) by flow cytometry
Methodological detailsflow cytometry, chart review
- Flow cytometry
- Chart review
Main finding
As reported in the abstract
- Non-classical monocytes showed a cell-type specific signature of high macrophage colony-stimulating factor (M-CSF) receptor CD115 and low granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor CD116 expression, separating them from the other two monocyte subsets
- In healthy individuals, CD115 on non-classical monocytes was age-dependent, with lower expression in young adults
- SLE: marked expansion of CD115+ non-classical monocytes in patients of all ages
- Expanded CD115+ non-classical monocytes associated with LN but not with disease activity, and coexpressed slan
Observational data: associations, not effects.
Original publication
Macrophage colony-stimulating factor receptor/CD115 + non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis. Scand J Rheumatol. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →