The incidence and risk factors of uveitis in children with juvenile idiopathic arthritis (JIA): a meta -analysis and literature review
Authors' conclusion
The notable prevalence of uveitis in JIA demands clinical vigilance. Our study findings highlight that age, ANA status, and ESR correlate with risk of complicated uveitis.
Study context
- Population
- Children with JIA; PubMed, Cochrane, Embase and Web of Science searched until December 31, 2023
- Participants
- 22,834 children28 studies
- Outcome
- Incidence of uveitis in JIA and its risk factors
Methodological detailsNewcastle-Ottawa Scale quality assessment
- Newcastle-Ottawa Scale quality assessment
Pooled result
As reported in the abstract
Overall prevalence of uveitis in JIA
Overall prevalence
12.7%
95% CI 10.5–15.1%
Developed uveitis during follow-up
3,381
Further pooled results
Prevalence of uveitis by region
- European populations
- 14.3% (95% CI: 11.9 - 15.1%)
- Asian populations
- 6.5% (95% CI: 4.0 - 9.5%)
- North America
- 13.4% (95% CI: 9.5 - 17.8%)
Risk factors for uveitis
- Identified risk factors: early age at JIA onset, ANA-positive, increased ESR
Original publication
The incidence and risk factors of uveitis in children with juvenile idiopathic arthritis (JIA): a meta -analysis and literature review. Pediatr Rheumatol Online J. Published 14 July 2025. doi:10.
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