Lupus & antiphospholipid syndrome
The efficacy of induction treatment in Thai patients with lupus nephritis: Observational cohort analysis
Authors' conclusion
The induction treatment with either IVCYC or MMF had similar efficacy in Thai LN patients.
Study context
- Population
- Thai adults with active proliferative lupus nephritis (LN) confirmed by renal biopsy, January 2013–June 2021
- Participants
- 93 adults
- Exposure
- IVCYC vs mycophenolate mofetil (MMF) induction treatment
- IVCYCn = 40
- MMFn = 53
- Outcome
- CR
- Follow-up
- 24 weeks
Main finding
As reported in the abstract
- Unadjusted complete remission (CR) risk difference (groups' order not stated)
- −0.08 (95% CI −0.26, −0.09, p-value = 0.351)
- Adjusted CR risk difference (groups' order not stated)
- −0.19 (95% CI −0.42, 0.04, p-value = 0.098)
Observational data: associations, not effects.
Secondary outcomes
Overall remission (OR)
- Unadjusted OR risk difference (groups' order not stated)
- −0.06 (95% CI −0.26, 0.14, p-value = 0.553)
- Adjusted OR risk difference (groups' order not stated)
- −0.24 (95% CI −0.50, 0.02, p-value = 0.067)
Urine protein creatinine ratio (UPCR) change over time
- Unadjusted UPCR mean (groups' order not stated)
- −0.29 (95% CI −0.77, 0.17, p-value = 0.210)
- Adjusted UPCR mean (groups' order not stated)
- −0.27 (95% CI −0.88, 0.32, p-value = 0.366)
Original publication
The efficacy of induction treatment in Thai patients with lupus nephritis: Observational cohort analysis. Lupus. Published 5 January 2023. doi:10.
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