The effect of hypersensitive C-reactive protein to albumin ratio on the risk of fragility fracture in the Chinese male population
Main finding · Incident fragility fracturesResult — go to the resultHazard ratio 1.49 95% CI 1.21–1.84Authors' conclusion
Elevated levels of CAR were associated with an increased risk of fragility fractures and that this association was robust to adjustment for multiple potential confounders.
Study context
- Population
- Chinese male participants aged 18–98 years (average age 53.92 years) from the Kailuan Study, followed up until 2022728 incident fragility fractures
- Participants
- 48,186 participants
- Exposure
- Highest vs second quartile of hs-CRP to albumin ratio
- Outcome
- Incident fragility fractures
- Follow-up
- Average 11.17 years
Methodological detailsCox proportional hazards model, restricted cubic splines
- Cox proportional hazards model
- Restricted cubic splines
Main finding
As reported in the abstract
average follow-up 11.17 years
Hazard ratio
1.49
95% CI 1.21–1.84
Highest quartile of CARvs Second quartile of CAR
HR 1.49 (95% CI 1.21–1.84)
Observational data: associations, not effects.
Further findings
| Outcome | CAR | hs-CRP | Albumin |
|---|---|---|---|
| Incremental predictive value for fragility fractures: CAR vs hs-CRP vs albumin | |||
| C-index | 61.142% | 0.6137 | 0.6116 |
| Continuous NRI | 0.089 (p < 0.05) | — not stated in the abstract | — not stated in the abstract |
| IDI | 0.00009 (p < 0.05) | 0.000074 | - 0.000004 |
| NRI | — not stated in the abstract | 0.086 | 0.068 |
— not stated in the abstract
Original publication
The effect of hypersensitive C-reactive protein to albumin ratio on the risk of fragility fracture in the Chinese male population. Osteoporos Int. Published 21 February 2025. doi:10.
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