Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO
Recommendations
As issued by the authors
In patients with or at risk of osteoporosis, measure 25(OH)D concentration before supplementation and give vitamin D (optimising calcium intake if needed) to obtain a concentration between 30 and 60ng/mL
Use an initial loading dose, especially where quick repletion is needed (symptoms of osteomalacia and/or 25(OH)D <12ng/mL, patients eligible for potent antiresorptive therapy), followed by a maintenance dose
Daily supplementation should be the rule when possible
Where daily forms are not available or not reimbursed, continue intermittent dosing with the smallest available dose (≤50,000IU) and the shortest interval between doses as a stopgap until reimbursement or adequate daily forms (pills or soft capsules of 1000, 2000IU) are available
Original publication
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