Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US
Authors' conclusion
Except among female fracture patients in the US, hyperlipidemia was the most prevalent comorbidity among Chinese and US fragility fracture patients. US fracture patients demonstrated a similar complex comorbidity network to non-fracture individuals.
Study context
- Population
- Fragility fracture patients aged ≥ 50 years in China (single hospital inpatients) and the US (National Health and Nutrition Examination Survey (NHANES))73% females
- Exposure
- Chinese vs US fragility fracture patients; US fracture patients vs matched non-fracture individuals
- Outcome
- Multimorbidity patterns (comorbidity prevalence, disease pairs, complexity of comorbidity network by average degree)
Methodological detailsinpatient electronic medical records (China, 2018–2023) and NHANES 1999-2020, NHANES fracture patients matched to non-fracture individuals by age (< 1 year), sex and survey cycle, comorbidity network analysis (average degree)
- Inpatient electronic medical records (China, 2018–2023) and NHANES 1999-2020
- NHANES fracture patients matched to non-fracture individuals by age (< 1 year), sex and survey cycle
- Comorbidity network analysis (average degree)
Main finding
As reported in the abstract
Chinese fracture patients: hyperlipidemia, male
63.3%
Chinese fracture patients: hyperlipidemia, female
65.2%
US fracture patients: hyperlipidemia, males
67.3%
US fracture patients: osteoporosis, females
78.3%
Observational data: associations, not effects.
Further findings
| Outcome | US fracture | Non-fracture individuals |
|---|---|---|
| Comorbidity network complexity (average degree), males | 7.82 | 7.59 |
| Comorbidity network complexity (average degree), females | 7.94 | 7.44 |
Most prevalent disease pair
- US fracture patients: osteoporosis and hyperlipidemia, male
- 40.8%
- US fracture patients: osteoporosis and hyperlipidemia, female
- 61.4%
- Chinese fracture patients: hypertension and hyperlipidemia, male
- 26.6%
- Chinese fracture patients: hypertension and hyperlipidemia, female
- 29.4%
Comorbidity network complexity (average degree), males
- Multimorbidity pattern of US fracture patients similar to non-fracture individuals
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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