Association of physical activity with fracture: a prospective cohort study of 387,307 Chinese participants
Authors' conclusion
High levels of physical activity, particularly OPA, are associated with an increased risk of fracture in Chinese middle-aged and older adults, whereas non-OPA shows no such association. Moderate activity was associated with a lower risk of hip fracture.
Study context
- Population
- Adults aged 40–79 years from the China Kadoorie Biobank8,964 fractures
- Participants
- 387,307 adults
- Exposure
- Quartiles of total physical activity (TPA, MET-h/day), with occupational (OPA) and non-OPA domains and moderate-to-vigorous physical activity (MVPA) duration
- Outcome
- Incident fracture
Methodological detailsCox models
- Cox models
Main finding
As reported in the abstract
Incident fracture by TPA quartile · median follow-up 10.1 years
Hazard ratio (95% CI)
TPA quartile 3
1.34(1.25–1.43)
TPA quartile 4
1.47(1.37–1.58)
Observational data: associations, not effects.
Further findings
Hip fracture
| HR (95% CI) | ||
|---|---|---|
| TPA quartile 2 | 0.82 (0.71–0.94) | |
| 0.512Hazard ratio (log scale) |
Fracture by MVPA duration
- MVPA of 300-449 min/week or ≥ 450 min/week associated with increased fracture risk
Original publication
Association of physical activity with fracture: a prospective cohort study of 387,307 Chinese participants. Osteoporos Int. Published 18 March 2026. doi:10.
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