Autoinflammatory & rare systemic diseases
The development and initial validation of IgG4-related disease damage index: a consensus report from Chinese IgG4-RD Consortium
Authors' conclusion
The IgG4-RD DI is a useful approach to analyse disease outcomes, and it has good operability and credibility.
Study context
- Population
- 40 IgG4-RD cases representing four clinical scenarios, each with two time points of assessment over at least 3 years of follow-up, rated by 48 rheumatologists from 35 hospitals in China48 raters
- Participants
- 40 cases
- Outcome
- Development, reliability and criterion validity of the IgG4-RD DI
Methodological detailsDelphi method, inter-rater reliability, criterion validity
- Delphi method
- Inter-rater reliability
- Criterion validity
Recommendations
As reported in the abstract
- Structure: cumulative index of 14 organ-system domains
- 39 items
- Intraclass correlation coefficient (ICC) at the two time points
- 0.69 and 0.70
- KW at the two time points
- 0.74 and 0.73
- Sensitivity
- 0.86 (95% CI 0.82 to 0.88)
- Specificity
- 0.79 (95% CI 0.76 to 0.82)
- AUC
- 0.88 (95% CI 0.85 to 0.91)
Further findings
Inter-rater reliability in subgroups
Over
- ICC in all subgroups
- 0.55
- KW in all subgroups
- 0.61
Original publication
The development and initial validation of IgG4-related disease damage index: a consensus report from Chinese IgG4-RD Consortium. RMD Open. Published 8 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →