Lupus & antiphospholipid syndrome
The clinicopathological features and renal prognostic factors in pure membranous lupus nephritis—a large series cohort study from China
Authors' conclusion
MLN mostly manifested as nephrotic syndrome, with few renal dysfunctions. Although MLN had a high relapse rate, most patients had a response to immunosuppressants and had a good renal outcome.
Study context
- Population
- Biopsy-proven pure membranous LN patients, Jinling Hospital, China, January 2010 to January 2020 (mean age 34 ± 12 years; 87.8% female)535 membranous lupus nephritis (MLN) screened
- Participants
- 456 patients
- Outcome
- ESKD (eGFR≤15 mL/min·1.73 m² or need for renal replacement therapy), doubling of serum creatinine, or eGFR decline of more than 40%
Methodological detailssingle-centre, Cox regression, Kaplan-Meier analysis
- Single-centre
- Cox regression
- Kaplan-Meier analysis
Main finding
As reported in the abstract
Renal endpoint:
- ESKD
- Doubling of serum creatinine
- eGFR decline >40%
Patients reaching the renal endpoint
37
8.1%
5-year renal survival rate
95.8%
10-year renal survival rate
89.4%
Observational data: associations, not effects.
Further findings
Treatment response
- Complete remission
- 370 (81.1%)
- Partial remission
- 43 (9.4%)
- No response
- 43
Relapse
- Relapse
- 34.4%
Nephrotic syndrome at presentation
- Nephrotic syndrome
- 62.1%
- Proteinuria
- 2.67 g/24h
Original publication
The clinicopathological features and renal prognostic factors in pure membranous lupus nephritis—a large series cohort study from China. Lupus. Published 30 December 2023. doi:10.
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