Systemic sclerosis & Raynaud's
The burden of illness of the organ manifestations of systemic sclerosis: a pragmatic, targeted review
Authors' conclusion
Organ manifestations experienced by patients with systemic sclerosis significantly affect patient quality of life and mortality.
Study context
- Population
- Patients with SSc with at least one of eight organ manifestations (ILD and/or pulmonary hypertension, skin, peripheral vascular, musculoskeletal, gastrointestinal, cardiac or renal involvement)
- Participants
- 50 studies
- Outcome
- Mortality, humanistic and economic burden of eight organ manifestations of SSc
Methodological detailsstructured, pragmatic, Searches of Ovid MEDLINE and EMBASE, PubMed and NHS Economic Evaluation Database in August 2023; studies published within the last 15 years, meta-analyses without publication limits
- Structured
- Pragmatic
- Searches of Ovid MEDLINE and EMBASE, PubMed and NHS Economic Evaluation Database in August 2023; studies published within the last 15 years, meta-analyses without publication limits
Main finding
As reported in the abstract
Studies reporting mortality outcomes (including 4 meta-analyses)
37
Studies reporting humanistic burden
9
Studies reporting economic burden outcomes
11
Original publication
The burden of illness of the organ manifestations of systemic sclerosis: a pragmatic, targeted review. Clin Exp Rheumatol. Published 5 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →