The Association of Osteoarthritis With De Novo Inflammatory Arthritis in Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Study
Authors' conclusion
OA was more prevalent among ICI-treated patients developing IA-irAE than those who were not. Hand OA was the most common OA pattern in IA-irAE patients. Preexisting OA, melanoma, and a family history of AID were associated with IA-irAE.
Study context
- Population
- Immune checkpoint inhibitor (ICI)-treated patients
- Participants
- 181 / 140 / 170
- Exposure
- IA-irAE vs non-IA irAE vs non-irAE ICI-treated patients
- IA-irAEn = 181
- non-IA irAEsn = 140reference
- non-irAEsn = 170reference
- Outcome
- Prevalence of preexisting OA
Methodological detailslogistic regression
- Logistic regression
Main finding
As reported in the abstract
Prevalence of OA
IA-irAE vs Non-IA irAE: P < 0.001 · IA-irAE vs Non-irAE: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | IA-irAE | P value |
|---|---|---|
| Predominant hand involvement among patients with OAIA-irAE vs Non-IA irAE | 62% | P < 0.001 |
| Predominant hand involvement among patients with OAIA-irAE vs Non-irAE | P < 0.001 |
- Predominant hand involvement among patients with osteoarthritis (OA): Non-IA irAE 13%
- Predominant hand involvement among patients with OA: Non-irAE 13%
Predominant hand involvement among patients with OA
- IA-irAE group had higher frequency of multisite OA
Risk factors for IA-irAE (logistic regression)
- Family history of autoimmune disease (AID), OR
- 2.03 (1.02-4.05) (95% CI)
- Preexisting OA, OR
- 2.88 (1.85-4.52) (95% CI)
- Melanoma, OR
- 2.63 (1.56-4.47) (95% CI)
Original publication
The Association of Osteoarthritis With De Novo Inflammatory Arthritis in Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Study. Arthritis Care Res (Hoboken). Published 1 June 2026. doi:10.
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