Lupus & antiphospholipid syndrome
Systemic lupus erythematosus and toll-like receptor 9 polymorphisms: A meta-analysis of genetic association studies
Pooled resultResult — go to the resultOdds ratio 1.146 95% CI 1.033–1.273Authors' conclusion
SLE susceptibility is associated with the TLR9 rs187084 polymorphism in the Asian population and the rs187084, rs352139, rs352140, and rs5743836 polymorphisms in the Asian, European, and Latin American populations, respectively.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and controls in genetic association studies from MEDLINE, Embase and Web of Science26 trials from 24 articles
- Participants
- 5,447 vs 6,588
- Comparison
- TLR9 rs187084, rs352139, rs352140 and rs5743836 polymorphisms and SLE risk
- SLEn = 5,447
- Controlsn = 6,588reference
- Outcome
- Association of TLR9 polymorphisms with SLE risk
Pooled result
As reported in the abstract
Odds ratio
1.146
95% CI 1.033–1.273
P = 0.010
rs187084 T allele
OR 1.146 (95% CI 1.033–1.273); P = 0.010
Original publication
Systemic lupus erythematosus and toll-like receptor 9 polymorphisms: A meta-analysis of genetic association studies. Lupus. Published 2 June 2023. doi:10.
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