Synovial fluid survivin and NETs as independent biomarkers in rheumatoid arthritis
Authors' conclusion
We found an independent association between levels of survivin and NETs in SF with the exclusion of OA diagnosis, but not with RA activity.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) undergoing synovial fluid analysis
- Participants
- 32 vs 16
- Exposure
- Synovial fluid survivin and NETs in RA vs OA
- RAn = 32
- OAn = 16reference
- Outcome
- Synovial fluid survivin and NETs concentrations; correlation with exclusion of OA diagnosis and RA activity (DAS28)
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Synovial fluid survivin concentration
P = 0.0006
Observational data: associations, not effects.
Further findings
Synovial fluid NETs concentration
P = 0.004
ROC performance of synovial fluid (SF) survivin and NETs (RA vs OA)
- Survivin AUC
- 79%
- NETs AUC
- 75%
- Sensitivity (both)
- 75%
- Specificity (both)
- 78%
Correlation between survivin and NETs
- No correlation between survivin and NETs values for both groups
- Association between SF survivin and serum ACPA in RA
Original publication
Synovial fluid survivin and NETs as independent biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. Published 13 May 2022. doi:10.
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