Risk of Staphylococcus aureus bacteraemia in patients with rheumatoid arthritis and the effect of orthopaedic implants on the risk: a nationwide observational cohort study
Authors' conclusion
In this nationwide registry-based cohort study RA was a risk factor for SAB, and orthopaedic implants further increased the risk.
Study context
- Population
- Danish residents aged ≥ 18 years without prior rheumatoid arthritis (RA) or Staphylococcus aureus bacteraemia (SAB), followed 1996–201725,023 SAB events
- Participants
- 33,567 vs 5,398,690
- Exposure
- RA vs general population cohort; with vs without orthopaedic implants
- RAn = 33,567
- General population cohort (GPC)n = 5,398,690reference
- Outcome
- Microbiologically verified Staphylococcus aureus bacteraemia (SAB): IRs and IRRs
Methodological detailsage- and sex-stratified Poisson regression, adjusted for age, comorbidities, calendar year and socioeconomic status
- Age- and sex-stratified Poisson regression
- Adjusted for age, comorbidities, calendar year and socioeconomic status
Main finding
As reported in the abstract
SAB incidence rate per 100 000 person-years
Each group vs GPCEstimate (95% CI)
RA
adjusted IRR (women 18-59 years) 2.6(1.8–3.7)
RA
adjusted IRR (men 18-59 years) 1.8(1.1–3.1)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| SAB in RA patients with orthopaedic implants vs GPC without implantsRA cohort with implantsvs GPC without implantsLowest of range | IRR (women ≥ 70 years) 1.9 (CI 1.3–2.8) | |
| SAB in RA patients with orthopaedic implants vs GPC without implantsRA cohort with implantsvs GPC without implantsHighest of range | IRR (18-59-year-old men) 5.3 (CI 2.2–12.8) | |
| 0.050.21520Ratio (log scale) |
Original publication
Risk of Staphylococcus aureus bacteraemia in patients with rheumatoid arthritis and the effect of orthopaedic implants on the risk: a nationwide observational cohort study. Scand J Rheumatol. Published 20 April 2022. doi:10.
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