Rheumatoid arthritis and risk of osteoarticular infection and death following Staphylococcus aureus bacteraemia: a nationwide cohort study
Main finding · OAI, cumulative incidenceResult — go to the resultHazard ratio 1.93 95% CI 1.54–2.41Authors' conclusion
Following SAB, almost one in four patients with RA contracted OAI corresponding to a doubled risk compared with non-RA. In RA, orthopaedic implants and current TNFi use were associated with approximately doubled OAI risk. One in three died within 90 days in both RA and non-RA.
Study context
- Population
- All patients with microbiologically verified first-time Staphylococcus aureus bacteraemia (SAB), Denmark, 2006–18
- Participants
- 18,274 patients
- Exposure
- Rheumatoid arthritis (RA) vs non-RA following SAB
- RAn = 367
- Outcome
- Cumulative incidence of osteoarticular infection (OAI) following SAB
- Follow-up
- 90 days
Methodological detailsregistry-based, multivariate Cox regression
- Registry-based
- Multivariate Cox regression
Main finding
OAI, cumulative incidence
Hazard ratio
1.93
95% CI 1.54–2.41
By group
RAvs Non-RA
HR 1.93 (95% CI 1.54–2.41)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Osteoarticular infection (OAI) in RA patients with orthopaedic implants · 90 days
| HR (95% CI) | ||
|---|---|---|
| RA with orthopaedic implants | 1.75 (1.08–2.85) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | RA | Non-RA | HR (95% CI) | |
|---|---|---|---|---|
| OAI in RA current TNFi users · 90 daysCurrent TNFi usersvs Non-users | 2.27 (1.29–3.98) | |||
| All-cause mortality · 90 days | 35.4% (95% CI 30.6–40.3) | 33.9% (95% CI 33.2–34.5) | 1.04 (0.87–1.24) | |
| 0.20.5125Hazard ratio (log scale) |
- OAI in RA patients with orthopaedic implants: RA with orthopaedic implants 29.4% (95% CI 22.9–36.2)
- OAI in RA current tumor necrosis factor inhibitors (TNFi) users: Current TNFi users 41.9% (95% CI 27.0–56.1)
Original publication
Rheumatoid arthritis and risk of osteoarticular infection and death following Staphylococcus aureus bacteraemia: a nationwide cohort study. Rheumatology (Oxford). Published 9 March 2024. doi:10.
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