Autoinflammatory & rare systemic diseases
Symptom course of PFAPA syndrome
Authors' conclusion
In patients whose fever resolved, most experienced their last febrile episode before adolescence.
Study context
- Population
- Patients diagnosed with PFAPA syndrome at Versailles Hospital (Paris, France), included in the Juvenile Inflammatory Rheumatism (JIR) cohort, 2016 to February 202334 lost to follow-up
- Participants
- 209 patients
- Outcome
- Age at and delay to recovery (recovery = absence of any febrile PFAPA episode in the past year)
Methodological detailssingle-centre, medical record review, telephone follow-up
- Single-centre
- Medical record review
- Telephone follow-up
Main finding
As reported in the abstract
Recovery and symptom course
- Resolution of periodic fever
- 56 (27%)
- Still active
- 119 (57%)
- Lost to follow-up
- 34 (16%)
- Median duration of symptoms among recovered (Q1-Q3: 2.97-8.65)
- 5.43 years
- Median age at last febrile episode among recovered (Q1-Q3: 5.44-10.24)
- 8.34 years
Observational data: associations, not effects.
Further findings
Relapse after initial declaration of cure, among 119 with persistent fever
- Initially declared cured but relapsed
- 10
Original publication
Symptom course of PFAPA syndrome. Pediatr Rheumatol Online J. Published 29 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →