Strategic use of levofolinic acid for methotrexate-induced side effects in juvenile idiopathic arthritis: a prospective observational study
Authors' conclusion
LVF given 48 h before MTX significantly reduced gastrointestinal side effects and did not reduce drug's efficacy.
Study context
- Population
- Patients with Juvenile Idiopathic Arthritis (JIA) reporting significant gastrointestinal discomfort after methotrexate (MTX) despite LVF 48 h after MTX; anticipatory symptoms excludedfollowed ≥12 months
- Participants
- 21 patients
- Exposure
- LVF supplemental dose 48 h before MTX added to LVF 48 h after MTX
- LVFn = 21
- Outcome
- Complete remission of gastrointestinal side effects
Main finding
As reported in the abstract
first visit (T1)
LVF
61.9%
- T2
- 85.7%
- T3
- 95.2%
- T4
- 85.7%
- T5
- 100%
Observational data: associations, not effects.
Further findings
MTX efficacy: change in JADAS and CRP from T1 to T4
- Significant reduction of JADAS
- P = 0.006
- Significant reduction of CRP
- 0.008
MTX withdrawn for remission
- MTX withdrawn for remission
- 7/21
Original publication
Strategic use of levofolinic acid for methotrexate-induced side effects in juvenile idiopathic arthritis: a prospective observational study. Pediatr Rheumatol Online J. Published 15 February 2023. doi:10.
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