Significant pain decrease in children with non-systemic Juvenile Idiopathic Arthritis treated to target: results over 24 months of follow up
Authors' conclusion
Treatment-to-target seems effective in pain-reduction in non-systemic JIA-patients irrespective of initial treatment-strategy.
Study context
- Population
- DMARD-naïve children with non-systemic JIA
- Participants
- 92 children
- Comparison
- Initial sequential DMARD monotherapy vs initial methotrexate (MTX)/prednisolone bridging vs initial MTX/etanercept
- Primary endpoint
- VAS pain scores (0-100 mm) over time between treatment strategies
- Follow-up
- 24 months
Methodological detailsthree treatment strategies, treat-to-target, linear mixed models
- Three treatment strategies
- Treat-to-target
- Linear mixed models
Primary result
As reported in the abstract
VAS pain over time, interaction treatment arm*time (months)
β
0.13
95% CI −0.36 to 0.62
Arm 1
β
0.37
95% CI −0.12 to 0.86
Arm 2
Further findings
VAS pain, all patients · 24 months
- Mean pain score at baseline (SD 21.7) mm
- 55.3
- Mean pain score after 24 months (SD 25.3) mm
- 19.5
- Mean change per month, β mm
- −1.37 (95% CI −1.726; −1.022)
- Decreased significantly
Baseline predictors of pain over time (multivariable model), β (95% CI)
- Higher VAS pain (0.25; 0.65), higher pain
- 0.44
- Higher active joint count (0.19; 1.34), higher pain
- 0.77
- Low VAS physician (−0.55; −0.06), lower pain
- −0.34
- CHQ Physical summary score (−0.72; −0.11), lower pain
- −0.42
- CHQ Psychosocial summary score (−0.77; −0.06), lower pain
- −0.42
Original publication
Significant pain decrease in children with non-systemic Juvenile Idiopathic Arthritis treated to target: results over 24 months of follow up. Pediatr Rheumatol Online J. Published 26 August 2023. doi:10.
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