Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease
Authors' conclusion
For patients with fever of unknown etiology and lymphadenopathy, after excluding HLH or MAS, serum IFN-γ > 8.56 pg/mL and IFN-γ/IL-6 ratio > 0.45 may highly suggest the diagnosis of KFD; serum IL-6 > 50.45 pg/mL indicates that the probability of KFD may be small, and sJIA, KD, and acute infection should be excluded first.
Study context
- Population
- Children with Kikuchi-Fujimoto disease, Shenzhen Children's Hospital, January 2015 to November 202125 with serum cytokines
- Participants
- 57 children
- Exposure
- Kikuchi-Fujimoto disease (KFD) vs sJIA and vs KD
- KFDn = 25
- Outcome
- Serum cytokines (IFN-γ, IL-6, IFN-γ/IL-6 ratio) for differentiating KFD from sJIA or KD
Methodological detailssingle-centre, ROC curve analysis
- Single-centre
- ROC curve analysis
Main finding
As reported in the abstract
Serum IFN-γ
KFD vs SJIA: P = 0.16 · KFD vs KD: P = 0.01
Observational data: associations, not effects.
Further findings
Diagnostic cutoffs, KFD vs SJIA
- IFN-γ cutoff
- > 8.48 pg/ml
- IL-6 cutoff
- < 47.42 pg/ml
- IFN-γ/IL-6 ratio cutoff
- > 0.45
- Specificity of all cutoffs
- ≥ 94.7%
Diagnostic cutoffs, KFD vs KD
- IFN-γ cutoff
- > 8.56 pg/ml
- IL-6 cutoff
- < 50.45 pg/ml
- IFN-γ/IL-6 ratio cutoff
- > 0.45
- Specificity of all cutoffs
- ≥ 94.7%
Original publication
Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease. Pediatr Rheumatol Online J. Published 22 August 2023. doi:10.
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