Lupus & antiphospholipid syndrome

Stigma, discrimination-related events, and determinants among adult people living with systemic lupus erythematosus (SLE): Systematic review and indicator-level meta-analysis

LupusPublished Systematic review and meta-analysis of observational studies

Authors' conclusion

This review demonstrates that stigma and discrimination are not just social challenges but also critical determinants of health.

Study context

Population
Adults living with SLE
Participants
2,254 adults11 studies
Outcome
Prevalence and determinants of stigma
Methodological detailsindicator-level meta-analysis, dual independent screening, Newcastle-Ottawa Scale risk-of-bias assessment
  • Indicator-level meta-analysis
  • Dual independent screening
  • Newcastle-Ottawa Scale risk-of-bias assessment

Pooled result

As reported in the abstract

Overall burden of stigma (moderate), pooled score

34.71

95% CI 26.15, 43.27

Experienced at least one form of stigma or discrimination

46%

95% CI 28–66%

Further pooled results

Determinants of stigma

Mental health associations correlated with higher stigma burden

Original publication

Stigma, discrimination-related events, and determinants among adult people living with systemic lupus erythematosus (SLE): Systematic review and indicator-level meta-analysis. Lupus. Published 8 August 2026. doi:10.1177/09612033261474062

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