Vasculitis & polymyalgia rheumatica
Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response
Authors' conclusion
Our findings reveal an immunopathologic signature in GCA at diagnosis, characterised by plasma cell-rich infiltrates associated with favourable outcomes, and ECM- and T cell-associated inflammation enriched in GC-refractory cases.
Study context
- Population
- Giant cell arteritis (GCA)-affected arterial tissues obtained at disease onset
- Comparison
- Sustained remission vs non-remission under GC monotherapy
- Outcome
- Tissue markers at disease onset distinguishing SR from NR
Methodological detailsspatial biology techniques, immunohistochemistry corroboration
- Spatial biology techniques
- Immunohistochemistry corroboration
Main finding
As reported in the abstract
- NR: upregulation of extracellular matrix remodelling (ECM) and T cell activation pathways
- Sustained remission (SR): enrichment of IgG-producing plasma cells in the adventitia, correlated with increased macrophage infiltration in the intima
- Combining plasma cell and macrophage markers could accurately predict GC responsiveness
Original publication
Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response. Ann Rheum Dis. Published 18 October 2025. doi:10.
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