Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study
Authors' conclusion
Gout patients exhibit decreased lumbar muscle quality compared with controls, consistent with an association between gout and sarcopenia.
Study context
- Population
- Gout subjects and non-gout controls aged 45–80 undergoing CT of the lumbosacral spine (psoas and erector spinae muscles at L3)45 gout and 25 controls analysed
- Participants
- 70 subjects
- Exposure
- Gout vs non-gout controls
- Goutn = 45
- Controlsn = 25reference
- Outcome
- Lumbar muscle quantity (SMA, SMI) and quality (SMRA, IMAT area, IMATI)
Methodological detailsCT imaging of the lumbosacral spine, adjusted for potential confounders
- CT imaging of the lumbosacral spine
- Adjusted for potential confounders
Main finding
As reported in the abstract
- Lumbar SMRA significantly lower in gout vs controls (reduced muscle quality)
- Lumbar IMAT area and IMATI significantly higher in gout vs controls (increased muscle adiposity)
- No significant difference in lumbar SMA or SMI between gout and controls
- Differences persisted after adjusting for potential confounders
Observational data: associations, not effects.
Original publication
Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study. Joint Bone Spine. Published 23 May 2024. doi:10.
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