Site-level cutaneous phenotyping framework for anti-MDA5-positive dermatomyositis: exploratory associations with systemic immune reference markers
Authors' conclusion
Site-by-lesion cutaneous phenotyping may provide a useful framework for studying phenotypic heterogeneity in anti-MDA5-positive dermatomyositis.
Study context
- Population
- Anti-MDA5-positive DM patients, single centre
- Participants
- 339 patients
- Outcome
- Associations of site-by-lesion cutaneous phenotype with systemic immune reference markers
Methodological detailssingle-centre, retrospective, exploratory
- Single-centre
- Retrospective
- Exploratory
Main finding
As reported in the abstract
Any cutaneous ulceration and CD8 + T-cell depletion, OR (P < 0.001; FDR q = 0.026)
3.35
Ulcer site count and CD8 + depletion, OR per site, independent (P = 0.008)
1.43
Facial ulceration and PAH, OR (P = 0.003); stronger than overall ulcer site count
2.28
Observational data: associations, not effects.
Original publication
Site-level cutaneous phenotyping framework for anti-MDA5-positive dermatomyositis: exploratory associations with systemic immune reference markers. Arthritis Res Ther. Published 6 June 2026. doi:10.
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