Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region
Authors' conclusion
We revealed that DM and PM share genetic susceptibility with common B cell lymphoma subtypes in both immune-related loci and loci with unclear biological functions.
Study context
- Population
- GWAS summary statistics of diffuse large B cell lymphoma, follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and marginal zone lymphoma, and of dermatomyositis (DM) and polymyositis (PM) from a GWAS and an ImmunoChip study
- Comparison
- DM and PM vs B cell lymphoma subtypes
- Outcome
- Shared genetic susceptibility: local genetic correlation (rg) for each disease pair (Bonferroni-corrected p<0.05) and jointly associated variants (conjunctional false discovery rate <0.05)
Methodological detailslocal analysis of (co)variant association, pleiotropy-informed conjunctional false discovery rate, functional mapping and annotation
- Local analysis of (co)variant association
- Pleiotropy-informed conjunctional false discovery rate
- Functional mapping and annotation
Main finding
As reported in the abstract
Significant rg across loci (half in the human leucocyte antigen (HLA) region)
16 loci
Range of significant rg
−0.50 to 0.84
Further findings
Functional analyses of non-HLA loci with significant rg
- Immune-related responses potentially overlapping between DM and FL, DM and CLL, and PM and CLL
Original publication
Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region. RMD Open. Published 25 August 2025. doi:10.
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