Sexual dysfunction in male patients treated with methorexate for arthritis: Analysis of the International Index of Erectile Function (IIEF5) questionnaire and hormonal status
Authors' conclusion
MTX exposure was associated with a lower IIEF5 score in male patients adjusted for age.
Study context
- Population
- Male patients with inflammatory arthritis (RA or PsA) with good disease control
- Participants
- 109 patients
- Exposure
- Chronic methotrexate (MTX) vs no MTX in male patients with inflammatory arthritis
- MTXn = 77
- Controlsn = 32reference
- Outcome
- Erectile function (IIEF5 questionnaire) and hormonal dosage
Methodological detailsage-matched controls, Median weekly MTX dose 10mg (IQR 7.5); median MTX therapy duration 8 years (IQR 17)
- Age-matched controls
- Median weekly MTX dose 10mg (IQR 7.5); median MTX therapy duration 8 years (IQR 17)
Main finding
As reported in the abstract
Total IIEF5 score
Negative correlation of total IIEF5 score with MTX time exposure (r)
r=−0.20 CI
−0.38 to −0.04P=0.039
MTX exposure associated with lower IIEF5 score adjusted for age (β estimate)
β Estimate=−2.63; CI
−5.13 to −0.13P=0.039
Observational data: associations, not effects.
Further findings
| Outcome | Controls | P value |
|---|---|---|
| Total IIEF5 score, MTX ≥5 years vs non-MTX and vs MTX <5 years (subgroup)MTX ≥5 years vs Controls | 20 (IQR 7.7) | P = 0.04 |
| Total IIEF5 score, MTX ≥5 years vs non-MTX and vs MTX <5 years (subgroup)MTX ≥5 years vs MTX <5 years | P = 0.01 |
- Total IIEF5 score, MTX ≥5 years vs non-MTX and vs MTX <5 years (subgroup): MTX ≥5 years 17 (IQR 15)
- Total IIEF5 score, MTX ≥5 years vs non-MTX and vs MTX <5 years (subgroup): MTX <5 years 20 (IQR 7)
Hormonal dosage
- Similar in both groups for all hormones evaluated
Original publication
Sexual dysfunction in male patients treated with methorexate for arthritis: Analysis of the IIEF5 questionnaire and hormonal status. Joint Bone Spine. Published 4 March 2024. doi:10.
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