Sex differences in hemoglobin levels and five-year refracture risk in patients with osteoporotic fractures: a retrospective cohort analysis
Main finding · 5-year refracture by Hb level in females with Hb below 10.7 g/dL (nonlinear relationship, turning point 10.7 g/dL)Result — go to the resultHazard ratio 0.63 95% CI 0.48–0.83Authors' conclusion
The findings demonstrated a significant negative correlation between Hb levels and the likelihood of refracture in elderly female patients with OPFs and suggested that elderly females with recent OPFs and Hb levels below 10.7 g/dL may be at a higher risk of refracture.
Study context
- Population
- Inhabitants of Kunshan over 60 years old hospitalised for an OPF between January 1, 2017, and July 27, 2022
- Participants
- 1,906 inhabitants
- Exposure
- Hemoglobin (Hb) levels at admission and 5-year refracture risk, by sex
- Outcome
- Refracture within 5 years
- Follow-up
- 5 years
Methodological detailsCox proportional hazard regression, smoothed curve fitting and threshold analysis, Kaplan-Meier curves
- Cox proportional hazard regression
- Smoothed curve fitting and threshold analysis
- Kaplan-Meier curves
Main finding
As reported in the abstract
5-year refracture by Hb level in females with Hb below 10.7 g/dL (nonlinear relationship, turning point 10.7 g/dL)
Hazard ratio
0.63
95% CI 0.48–0.83
P = 0.0008
Hb levels below 10.7 g/dL
HR 0.63 (95% CI 0.48–0.83); P = 0.0008
Every 1 g/dL increase in Hb below 10.7, as printed
Observational data: associations, not effects.
Original publication
Sex differences in hemoglobin levels and five-year refracture risk in patients with osteoporotic fractures: a retrospective cohort analysis. Osteoporos Int. Published 6 June 2024. doi:10.
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