The impact of acute-phase reaction on mortality and re-fracture after zoledronic acid in hospitalized elderly osteoporotic fracture patients
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.97 95% CI 1.09–3.56Authors' conclusion
Our findings suggested a potential association between the occurrence of APR and increased mortality risk. An initial dose of ZOL following orthopedic surgery was found to be protective against re-fracture in older patients with OPFs.
Study context
- Population
- Patients 50 years old or older with newly identified hip/morphological vertebral osteoporotic fracture (OPF) receiving ZOL for the first time after orthopedic surgery; tertiary level A hospital, China
- Participants
- 674 patients
- Exposure
- Acute phase reaction (APR) after initial ZOL infusion vs no APR
- Outcome
- All-cause mortality
Methodological detailsregistry-based (prospectively collected database), single-centre, multivariate Cox proportional hazards, competing risks regression
- Registry-based (prospectively collected database)
- Single-centre
- Multivariate Cox proportional hazards
- Competing risks regression
Main finding
As reported in the abstract
Hazard ratio
1.97
95% CI 1.09–3.56
P = 0.02
APR+vs APR-
HR 1.97 (95% CI 1.09–3.56); P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | Sub-distribution HR (95% CI) | P value | |
|---|---|---|---|
| Re-fracture (mortality as competing risk)Adjusted competing risk regression | 0.27 (0.11–0.70) | P = 0.007 | |
| 0.10.31310Sub-distribution HR (log scale) |
Original publication
The impact of acute-phase reaction on mortality and re-fracture after zoledronic acid in hospitalized elderly osteoporotic fracture patients. Osteoporos Int. Published 29 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →