Acromegaly and the long-term fracture risk of the vertebra and hip: a national cohort study
Authors' conclusion
The patients with acromegaly had a higher risk of hip fractures as well as clinical vertebral fractures than the controls. The increased fracture risk in patients with acromegaly was time-dependent and was observed even during the early period of follow-up.
Study context
- Population
- Patients with acromegaly aged ≥40 years in 2006–2016 and age- and sex-matched controls, national cohort (mean age 54.3 years; 58.9% female)matched cohort
- Participants
- 1,777 vs 8,885
- Exposure
- Acromegaly vs age- and sex-matched controls
- Acromegalyn = 1,777
- Controlsn = 8,885reference
- Outcome
- Clinical vertebral and hip fractures
- Follow-up
- ≈8.5 years
Methodological detailsnationwide population-based, age- and sex-matched, Cox proportional hazards model
- Nationwide population-based
- Age- and sex-matched
- Cox proportional hazards model
Main finding
As reported in the abstract
Each group vs controlsEstimate (95% CI)P value
Acromegaly
aHR (clinical vertebral fracture) 2.09(1.58–2.78)
P < 0.0001Acromegaly
aHR (hip fracture) 2.52(1.61–3.95)
P < 0.0001Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Clinical vertebral fractures, during and excluding the first 7 years of observationAcromegalyvs Controls | aHR (during first 7 years) 1.69 (95% CI 1.15–2.49) | |
| Clinical vertebral fractures, during and excluding the first 7 years of observationAcromegalyvs Controls | aHR (excluding first 7 years) 2.70 (95% CI 1.75–4.17) | |
| Hip fractures, during and excluding the first 7 years of observationAcromegalyvs Controls | HR (during first 7 years) 2.29 (95% CI 1.25–4.18) | |
| Hip fractures, during and excluding the first 7 years of observationAcromegalyvs Controls | HR (excluding first 7 years) 3.36 (95% CI 1.63–6.92) | |
| 0.10.31310Ratio (log scale) |
Original publication
Acromegaly and the long-term fracture risk of the vertebra and hip: a national cohort study. Osteoporos Int. Published 24 May 2023. doi:10.
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