Association of C-peptide level with bone mineral density in type 2 diabetes mellitus
Authors' conclusion
There is no significant linear relationship between FCP level and BMD or fracture risk in T2DM patients. In the FCP ≤ 1.14 ng/ml group, FCP is positively correlated with WB, LS, and FN BMD and negatively correlated with fracture risk, and FCP is an independent influencing factor of BMD and fracture risk.
Study context
- Population
- Patients with type 2 diabetes mellitus (T2DM)
- Participants
- 530 patients
- Exposure
- Fasting C-peptide (FCP) tertiles: FCP ≤ 1.14 ng/ml vs 1.14 < FCP ≤ 1.73 ng/ml vs FCP > 1.73 ng/ml
- Outcome
- Association of FCP with BMD (DXA) and 10-year probability of major osteoporotic and hip fractures (adjusted FRAX)
Methodological detailsFCP tertiles
- FCP tertiles
Main finding
As reported in the abstract
Association of FCP with BMD and fracture risk
- No significant linear relationship between FCP and bone mineral density (BMD) or fracture risk overall
- FCP ≤ 1.14 ng/ml: FCP positively correlated with whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD, negatively with fracture risk and osteoporotic fracture history; independent factor for BMD and fracture risk
- 1.14 < FCP ≤ 1.73 ng/ml and FCP > 1.73 ng/ml: FCP not correlated with BMD, fracture risk or osteoporotic fracture history
Observational data: associations, not effects.
Original publication
Association of C-peptide level with bone mineral density in type 2 diabetes mellitus. Osteoporos Int. Published 19 May 2023. doi:10.
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