Sex differences and predictors of anti-osteoporosis medication use in the 12 months after hip fracture surgery in adults 65 or older
Main finding · AOM use during the year post-fractureResult — go to the resultOdds ratio 0.42 95% CI 0.22–0.78Authors' conclusion
In older adults with hip fractures, AOM use is low over the year post-fracture and men are less likely to report AOM use compared to women which has implications for important sex differences in predictors of use.
Study context
- Population
- Adults aged 65 and older with hip fractures255 analysed
- Participants
- 312 adults
- Exposure
- Men vs women
- Menn = 151
- Womenn = 161reference
- Outcome
- AOM use, assessed at baseline (≤ 22 days of hospitalization) and at 2, 6 and 12 months post-hip fracture
- Follow-up
- 12 months post-fracture
Methodological detailsGeneralized estimating equations (GEE) models, follow-up at 2, 6 and 12 months
- GEE models
- Follow-up at 2, 6 and 12 months
Main finding
AOM use during the year post-fracture · 12 months
Odds ratio
0.42
95% CI 0.22–0.78
Menvs Women
OR 0.42 (95% CI 0.22–0.78)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Predictor of AOM use: baseline AOM use (by sex)Menvs WomenBaseline AOM use as predictor | 28.3 (5.4–148.0) | |
| Other predictor of AOM use in men: ageAge | 1.09 (1.01–1.18) | |
| 0.050.21520Odds ratio (log scale) |
Predictor of anti-osteoporosis medication (AOM) use: baseline AOM use (by sex)
| OR (95% CI) | ||
|---|---|---|
| WomenBaseline AOM use as predictor | 41.6 (14.0–123.0) | |
| 0.050.21520Odds ratio (log scale) |
Other predictors of AOM use in women
| OR (95% CI) | ||
|---|---|---|
| WomenOsteoporosis diagnosis | 3.19 (1.16–8.77) | |
| WomenMinimal alcohol use | 3.26 (1.34–7.94) | |
| 0.10.31310Odds ratio (log scale) |
AOM use, whole cohort
- Used AOM at baseline
- 53
- Initiated AOM use during follow-up
- 35
Original publication
Sex differences and predictors of anti-osteoporosis medication use in the 12 months after hip fracture surgery in adults 65 or older. Osteoporos Int. Published 2 August 2024. doi:10.
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